While Decalt is formulated for gentle, effective exfoliation, caution is advised when combining it with other potent actives, such as retinoids and L-ascorbic acid (Vitamin C). More stable forms of Vitamin C, such as magnesium ascorbyl phosphate or ascorbyl tetraisopalmitate, may be better tolerated but should still be used with care. To minimize the risk of irritation, consider alternating use (e.g Decalt and retinoids on alternating evenings (unless well tolerated), Vitamin C in the mornings) or using them on different days.